Biological Applications

The μRC can be used for a wide range of bio-chemical applications including binding studies (of proteins, lipids and enzymes) cell growth, organism metabolism and denaturation.
Several features of the μRC make it unique for study of these classes of materials including the incremental titration, temperature scanning, and stirring which, with the removable
cells of the micro reaction calorimeter mean that if your experiment precipitates or forms a gel you can simply dispose of the vial and start the next experiment with a clean one.

The THT Micro Reaction Calorimeter (µRC™) has a wide range of applications in the chemical, pharmaceutical and related fields. This brochure shows how using a microcalorimeter can help chemists and engineers in everyday tasks. 

Some of the applications detailed within this brochure include:

• Reaction Kinetics
• Process Development
• Scanning Calorimetry
• Thermal Stability
• Heat Capacity Measurement
• Adhesive Curing Reactions
• Waste Management
• End Point Determination
• Hazard Analysis

 All chemical, physical and biological reactions are accompanied by heat change. These reactions, though sometimes subtle, can be measured using calorimetry. This powerful analysis method works without modification of the sample or process. The THT Micro Reaction Calorimeter is based on power compensation technology making it faster in both signal response and temperature variation. Designed for maximum flexibility, the µRC has the capability to measure both kinetic and thermodynamic parameters in both rapid and slow reactions and in solids, liquids or gases. Measurements made by calorimetry are non-destructive and non-invasive making it valuable for initial analyses and for systems where other techniques fail. With the µRC there is minimal sample preparation and no limitation on the physical state of the material. Systems can be studied under ambient or modified environmental conditions.

Specification

• Baseline Noise: From 5μW
• Dynamic Range: 5μW to 600mW                                                      
• Temperature Range: -5°C to 170°C
• Standard Modes of Operation: Isothermal/Titration/ Scanning                                                      
• Optional Modes: Pressure - pressurise cell up to 10bar                                                                              

  

•  Scanning Rate: Up to 2°C/min
• Isothermal Stability: +/- 0.0001°C over extended time period                                                        
• Cell Volume: 1.5 ml
• Cell Type: Removable glass vial
• Injection Volume: 1 to 250 μl
• Temperature Control: Peltier based (no external cooling)
• Stirring Speed: 0 - 400 rpm
• Measurement Principle: Power compensation
• Connection to PC: via USB cable
• Footprint (width x depth x height): 19 x 31 x 35 cm
• Certain other specifications may be possible by discussion